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List of Publicly Traded Mid-Cap Biotech Companies Listed on Major U.S. Exchanges

This list includes mid-sized biotech companies with market capitalizations between two billion and ten billion dollars. We update this page at the start of every month so it is possible that during the course of a month a company’s market cap might fall below two billion or go above ten billion. Additional biotech companies can be found in the following sections:

List of Biotech Companies

Large-Cap Biotech Stocks

Small-Cap Biotech Stocks

Micro-Cap Biotech Stocks

Nano-Cap Biotech Stocks

Molecular Diagnostics

In parentheses you will find a short description or areas of focus for the company. A comparison widget that shows trend, earnings per share (EPS), P/E ratio and beta for each of the companies on this list can be accessed through the link below.

Mid-Cap Biotech Industry Comparison Widget

Select the company’s link to access charts, news links and company website and social media information.

Biotech: Mid-Cap Stocks

Alnylam Pharmaceuticals, Inc. (ALNY) (Biopharmaceutical company: RNAi therapeutics as genetic medicines; serious, life-threatening diseases)

Bio-Techne Corp (TECH) (Bioactive tools and resources used in the research and clinical diagnostic markets)

China Biologic Products, Inc. (CBPO) (China: plasma-based biopharmaceutical company)

Ionis Pharmaceuticals, Inc. (IONS) (RNA-targeted drug discovery and development: cancer, cardiovascular, metabolic, neurological disorders, rare diseases)

Jazz Pharmaceuticals Plc. (JAZZ) (Ireland, biopharmaceutical company: narcolepsy, lymphoblastic leukemia, hepatic veno-occlusive disease)

Ligand Pharmaceuticals Incorporated (LGND) (Biopharmaceutical company: licensing, royalty-generating assets)

Mallinckrodt Plc. (MNK) (Ireland, biopharmaceutical company: ADHD, autoimmune, central nervous system disorders, pain, rare diseases; medical imaging: contrast media and delivery systems, radiopharmaceuticals)

Nektar Therapeutics (NKTR) (Biopharmaceutical company: anti-infective, anti-viral, immunology, oncology, pain)

TiGenix NV (TIG) (IPO December 15, 2016: biopharmaceutical company, allogeneic stem cell therapies)


Galapagos NV (GLPG) (IPO in May 2015: Belgium: small molecule medicines; rheumatoid arthritis)


Qiagen N.V. (QGEN) (Netherlands: Sample & assay technologies: automated systems and consumable products; bioinformatics)


Agios Pharmaceuticals, Inc. (AGIO) (Biopharmaceutical company: cancer and rare genetic disorders of metabolism)

Clovis Oncology, Inc. (CLVS) (Biopharmaceutical company: cancer treatments; non-small cell lung cancer, ovarian cancer, pancreatic cancer, breast and lung cancers)

Exelixis, Inc. (EXEL) (Biopharmaceutical company: small molecule therapies used in the treatment of cancer)

Hutchison China MediTech Limited (HCM) (IPO March 17, 2016: Biopharmaceutical company focused on immunological diseases and oncology in addition to consumer health products)

Seattle Genetics, Inc. (SGEN) (Antibody-based therapies for the treatment of cancer)

Tesaro, Inc. (TSRO) (Biopharmaceutical company: oncology therapeutics and supportive care products)

Central Nervous System

ACADIA Pharmaceuticals Inc. (ACAD) (Biopharmaceutical company: central nervous system disorders)

Alkermes Plc. (ALKS) (Ireland, biopharmaceutical company: medicines for the treatment of central nervous system diseases)

Sage Therapeutics, Inc. (SAGE) (Biopharmaceutical company: rare central nervous system disorders)


Intercept Pharmaceuticals, Inc. (ICPT) (Biopharmaceutical company: orphan and more prevalent liver diseases)


Bioverativ Inc. (BIVV) (Biotech company: hemophilia and other rare blood disorders)


Neurocrine Biosciences, Inc. (NBIX) (Neurological and endocrine based diseases and disorders)


Horizon Pharma plc (HZNP) (Ireland, biopharmaceutical company: arthritis pain, rare diseases)

Rare Diseases

Bluebird Bio, Inc. (BLUE) (Gene therapy)

Ultragenyx Pharmaceutical Inc. (RARE) (Biopharmaceutical company: debilitating genetic diseases)


United Therapeutics Corporation (UTHR) (Pulmonary arterial hypertension)

Synthetic Biology

Intrexon Corporation (XON) (Products for the consumer, energy, food, health and environmental industries)

Related Links:

List of Biotech ETFs

List of Pharmaceutical Companies

Publicly Traded Companies by Sector and Industry

List of Healthcare Companies

Mid-Cap Stocks