List of Publicly Traded Nano-Cap Biotech Stocks Listed on Major U.S. Exchanges

This list includes biotech companies with market capitalizations under 50 million dollars. We update this page at the start of every month so it is possible that during the course of a month a company’s market cap might go above fifty million dollars. Additional biotech companies can be found in the following sections:

Large-Cap Biotech Stocks

Mid-Cap Biotech Stocks

Small-Cap Biotech Stocks

Micro-Cap Biotech Stocks

Molecular Diagnostics

Biotech Resources

A comparison widget that shows trend, earnings per share (EPS), P/E ratio and beta for each of the companies on this list can be accessed through the link below.

Nano-Cap Biotech Industry Comparison Widget

Select the company’s link to access charts, news links and company website and social media information.

Biotech: Nano-Cap Stocks

AEterna Zentaris Inc. (AEZS) (Canada, biopharmaceutical company: oncology, endocrinology and women’s health)

Benitec Biopharma LTD (BNTC) (IPO in August 2015: Australia, biopharmaceutical company: gene silencing technology)

China Pharma Holdings, Inc. (CPHI) (China, biopharmaceutical company: main focus for its therapeutics includes CNS, cardiovascular, cerebrovascular, wound recovery, digestive disease and infectious diseases)

Hemispherx BioPharma, Inc. (HEB) (Biopharmaceutical company: drug entities used in the treatment of viral and immune-based disorders)

iBio, Inc. (IBIO) (Develops pharmaceutical product applications through its iBioLaunch platform)

Immuron Ltd (IMRN) (IPO June 9, 2017; biopharmaceutical company: immunomodulator polyclonal antibodies)

Proteon Therapeutics, Inc. (PRTO) (Biopharmaceutical company: kidney and vascular diseases)

Soligenix, Inc. (SNGX) (Vaccines, biodefense, rare diseases)

Therapix Biosciences Ltd (TRPX) (IPO March 22, 2017; cannabinoid pharmaceuticals)

Xenetic Biosciences, Inc. (XBIO) (Biologic drugs; orphan oncology therapeutics)

Animal Health

ImmuCell Corporation (ICCC) (Biotechnology company focused on improving animal health and productivity in the dairy and beef industries)

Jaguar Animal Health (JAGX) (IPO in May 2015: Animal health: gastrointestinal products)


AmpliPhi Biosciences Corporation (APHB) (Biopharmaceutical company: bacterial infections)

Aptose Biosciences, Inc. (APTO) (Canada: therapeutics to treat life-threatening cancers; acute myeloid leukemia, high-risk myelodysplastic syndromes)

Aptevo Therapeutics Inc. (APVO) (Biosciences: oncology and hematology therapies)

Can-Fite Biopharma Ltd (CANF) (Israel: biopharmaceutical company: autoimmune-inflammatory and cancer diseases)

Cellectar Biosciences, Inc. (CLRB) (Agents to detect, treat and monitor a broad spectrum of cancers)

Cel-Sci Corporation (CVM) (Immunotherapy products for the treatment of cancer and infectious diseases)

Celsion Corporation (CLSN) (Oncology company: chemotherapies, immunotherapies and RNA- or DNA-based therapies)

Champions Oncology, Inc. (CSBR) (Solutions and services designed to personalize the development and use of oncology drugs)

Cleveland BioLabs, Inc. (CBLI) (Biopharmaceutical company: toll-like immune receptor activators; applications in radiation mitigation, oncology immunotherapy and vaccines)

Cyclacel Pharmaceuticals, Inc. (CYCC) (Biopharmaceutical company: oral therapies used in the treatment of cancer and other serious diseases)

CytRx Corporation (CYTR) (Biopharmaceutical company: research and development company specializing in oncology)

DelMar Pharmaceuticals, Inc. (DMPI) (Biopharmaceutical company focused on cancer therapies)

Heat Biologics, Inc. (HTBX) (Therapeutic vaccines to combat a wide range of cancers and infectious diseases)

ImmunoCellular Therapeutics, Ltd. (IMUC) (Immune-based therapies for the treatment of brain cancers and other cancers)

Kazia Therapeutics (KZIA) (Biotech company: oncology)

MabVax Therapeutics Holdings, Inc. (MBVX) (Monoclonal antibody-based therapeutics and vaccines for cancer)

Onconova Therapeutics, Inc. (ONTX) (Biopharmaceutical company: small molecule drug candidates used in the treatment of cancer)

OncoSec Medical Inc. (ONCS) (Technologies designed to stimulate the body’s immune system; cancer)

Sierra Oncology, Inc. (SRRA) (Oncology company)

XTL Biopharmaceuticals Ltd. (XTLB) (Israel, biopharmaceutical company: autoimmune diseases; blood cancer)

Cell Therapies

Cytori Therapeutics Inc. (CYTX) (Clinical stage company: cell therapies to treat cardiovascular disease and repair soft tissue defects)

Central Nervous System

Tonix Pharmaceuticals Holding Corp. (TNXP) (Medicines for common disorders of the central nervous system: fibromyalgia, post-traumatic stress disorder, episodic tension-type headache)

VistaGen Therapeutics, Inc. (VTGN) (Biopharmaceutical company focused on treatments for central nervous system disorders)


Auris Medical Holding AG (EARS) (Switzerland: inner ear therapies)


AzurRx BioPharma, Inc. (AZRX) (IPO October 11, 2016: Development stage biopharmaceutical company focused on gastrointestinal disorders)


ARCA Biopharma, Inc. (ABIO) (Biopharmaceutical company: therapies for cardiovascular diseases)

Bellerophon Therapeutics, Inc. (BLPH) (Cardiopulmonary and cardiac diseases)


Catalyst Biosciences, Inc. (CBIO) (Biopharmaceutical company: hemostasis)


Caladrius Biosciences, Inc. (CLBS) (Immunotherapy company: cell process optimization, development, and manufacturing)

Stellar Biotechnologies, Inc. (SBOT) (Immunotherapy)

Infectious Diseases

Vical Incorporated (VICL) (Biopharmaceutical company: infectious diseases through DNA delivery technologies and therapeutic approaches)


Acasti Pharma, Inc. (ACST) (Canada, biopharmaceutical company: active pharmaceutical ingredients (API) for the management of cardiometabolic disorders)

Viking Therapeutics (VKTX) (IPO in April 2015: Therapeutics for patients suffering from metabolic and endocrine disorders)

Muscle Health

MYOS Corporation (MYOS) (BioTherapeutics and BioNutrition company: muscle health and function)


Cerecor Inc. (CERCU) (IPO in October 2015: Biopharmaceutical company: neurological and psychiatric diseases)

Marinus Pharmaceuticals, Inc. (MRNS) (Biopharmaceutical company: neuropsychiatric therapeutics)

Prana Biotechnology Ltd. (PRAN) (Australia: neurodegenerative diseases, Alzheimer’s and Huntington diseases)

Oral Health

Oragenics, Inc. (OGEN) (Biopharmaceutical company: oral probiotics products and antibiotics for humans and companion pets)


Kitov Pharamceuticals Holdings Ltd. (KTOV) (Israel: anti-inflammatory drugs that treat pain without raising blood pressure)

Pain Therapeutics (PTIE) (Biopharmaceutical company; painkillers)

Rare Diseases

Bio Blast Pharma Ltd. (ORPN) (Therapies for patients with rare and ultra-rare genetic diseases)

Soleno Therapeutics, Inc. (SLNO) (Rare diseases)

Regenerative Medicine

Cesca Therapeutics Inc. (KOOL) (Cell-based therapeutics for use in regenerative medicine)


Fibrocell Science Inc. (FCSC) (Cell and gene therapy company: rare and serious skin and connective tissue diseases)

RXI Pharmaceuticals Corporation (RXII) (Therapeutics in the areas of dermatology and ophthalmology)

Stem Cells

Cellect Biotechnology Ltd. (APOP) (IPO July 29, 2016: biotech company with functional stem cells selection platform)


Apricus Biosciences, Inc. (APRI) (Biopharmaceutical company: sexual health therapies, urology and rheumatology)


Altimmune, Inc. (ALT) (Immunotherapeutics and vaccines)

BiondVax Pharmaceuticals Ltd. (BVXV) (IPO in May 2015: Israel, biopharmaceutical company: flu vaccine)

Women’s Health

Dare Bioscience, Inc. (DARE) (Women’s reproductive health)

Veru Inc. (VERU) (Biopharmaceutical company: men’s and women’s health, FC2 female condom)