List of Publicly Traded Nano-Cap Biotech Stocks Listed on Major U.S. Exchanges

This list includes biotech companies with market capitalizations under 50 million dollars. We update this page at the start of every month so it is possible that during the course of a month a company’s market cap might go above fifty million dollars. Additional biotech companies can be found in the following sections:

Large-Cap Biotech Stocks

Mid-Cap Biotech Stocks

Small-Cap Biotech Stocks

Micro-Cap Biotech Stocks

Molecular Diagnostics

Biotech Resources

A comparison widget that shows trend, earnings per share (EPS), P/E ratio and beta for each of the companies on this list can be accessed through the link below.

Nano-Cap Biotech Industry Comparison Widget

Select the company’s link to access charts, news links and company website and social media information.

Biotech: Nano-Cap Stocks

AEterna Zentaris Inc. (AEZS) (Canada, biopharmaceutical company: oncology, endocrinology and women’s health)

Benitec Biopharma LTD (BNTC) (IPO in August 2015: Australia, biopharmaceutical company: gene silencing technology)

Cellect Biotechnology Ltd. (APOP) (IPO July 29, 2016: biotech company with functional stem cells selection platform)

China Pharma Holdings, Inc. (CPHI) (China, biopharmaceutical company: main focus for its therapeutics includes CNS, cardiovascular, cerebrovascular, wound recovery, digestive disease and infectious diseases)

Hemispherx BioPharma, Inc. (HEB) (Biopharmaceutical company: drug entities used in the treatment of viral and immune-based disorders)

iBio, Inc. (IBIO) (Develops pharmaceutical product applications through its iBioLaunch platform)

Mast Therapeutics, Inc. (MSTX) (Biopharmaceutical company: sickle cell disease, heart failure)

Proteon Therapeutics, Inc. (PRTO) (Biopharmaceutical company: kidney and vascular diseases)

Soligenix, Inc. (SNGX) (Vaccines, biodefense, rare diseases)

Xenetic Biosciences, Inc. (XBIO) (Biologic drugs; orphan oncology therapeutics)

Animal Health

ImmuCell Corporation (ICCC) (Biotechnology company focused on improving animal health and productivity in the dairy and beef industries)

Jaguar Animal Health (JAGX) (IPO in May 2015: Animal health: gastrointestinal products)

Nexvet Biopharma Plc. (NVET) (IPO in February 2015: Clinical-stage biopharmaceutical company; animal health products for dogs and cats)

Antibodies

Lpath, Inc. (LPTN) (Monoclonal antibodies that target bioactive lipids)

XOMA Corporation (XOMA) (Therapeutic antibodies; endocrine assets with the potential address multiple indications)

Cancer

AmpliPhi Biosciences Corporation (APHB) (Biopharmaceutical company: bacterial infections)

Aptose Biosciences, Inc. (APTO) (Canada: therapeutics to treat life-threatening cancers; acute myeloid leukemia, high-risk myelodysplastic syndromes)

Aptevo Therapeutics Inc. (APVO) (Biosciences: oncology and hematology therapies)

Can-Fite Biopharma Ltd (CANF) (Israel: biopharmaceutical company: autoimmune-inflammatory and cancer diseases)

Cellectar Biosciences, Inc. (CLRB) (Agents to detect, treat and monitor a broad spectrum of cancers)

Cel-Sci Corporation (CVM) (Immunotherapy products for the treatment of cancer and infectious diseases)

Celsion Corporation (CLSN) (Oncology company: chemotherapies, immunotherapies and RNA- or DNA-based therapies)

Cerulean Pharma Inc. (CERU) (NDCs designed to selectively attack tumor cells and reduce toxicity)

Champions Oncology, Inc. (CSBR) (Solutions and services designed to personalize the development and use of oncology drugs)

Cleveland BioLabs, Inc. (CBLI) (Biopharmaceutical company: toll-like immune receptor activators; applications in radiation mitigation, oncology immunotherapy and vaccines)

Cyclacel Pharmaceuticals, Inc. (CYCC) (Biopharmaceutical company: oral therapies used in the treatment of cancer and other serious diseases)

CytRx Corporation (CYTR) (Biopharmaceutical company: research and development company specializing in oncology)

DelMar Pharmaceuticals, Inc. (DMPI) (Biopharmaceutical company focused on cancer therapies)

Galectin Therapeutics Inc. (GALT) (Therapies for fibrotic diseases and cancer)

Heat Biologics, Inc. (HTBX) (Therapeutic vaccines to combat a wide range of cancers and infectious diseases)

ImmunoCellular Therapeutics, Ltd. (IMUC) (Immune-based therapies for the treatment of brain cancers and other cancers)

MabVax Therapeutics Holdings, Inc. (MBVX) (Monoclonal antibody-based therapeutics and vaccines for cancer)

Mirna Therapeutics Inc. (MIRN) (IPO in October 2015: Biopharmaceutical company: microRNA-based oncology therapeutics)

Novogen Limited (NVGN) (Australia, bio-pharmaceutical company: Drug technology platforms with applications across a range of oncology indications)

OncoGenex Pharmaceuticals Inc. (OGXI) (Therapeutics that target mechanisms of treatment resistance in cancer)

Onconova Therapeutics, Inc. (ONTX) (Biopharmaceutical company: small molecule drug candidates used in the treatment of cancer)

OncoSec Medical Inc. (ONCS) (Technologies designed to stimulate the body’s immune system; cancer)

ProNAi Therapeutics Inc. (DNAI) (IPO in July 2015, Canada; Oncology company: therapeutics based on their DNA interference technology platform)

Rexahn Pharmaceuticals, Inc. (RNN) (Biopharmaceutical company: therapeutics for the treatment of cancer)

Threshold Pharmaceuticals, Inc. (THLD) (Therapeutic agents that selectively target tumor cells)

Tokai Pharmaceuticals, Inc. (TKAI) (Therapies for cancer; prostate cancer)

Verastem, Inc. (VSTM) (Biopharmaceutical company: drugs to treat cancer by the targeted killing of cancer stem cells)

XTL Biopharmaceuticals Ltd. (XTLB) (Israel, biopharmaceutical company: autoimmune diseases; blood cancer)

Cell Therapies

Cytori Therapeutics Inc. (CYTX) (Clinical stage company: cell therapies to treat cardiovascular disease and repair soft tissue defects)

Neuralstem, Inc. (CUR) (Production of central nervous system stem cells used in the treatment of central nervous system diseases)

Central Nervous System

Tonix Pharmaceuticals Holding Corp. (TNXP) (Medicines for common disorders of the central nervous system: fibromyalgia, post-traumatic stress disorder, episodic tension-type headache)

VistaGen Therapeutics, Inc. (VTGN) (Biopharmaceutical company focused on treatments for central nervous system disorders)

Diagnostics

Transgenomic, Inc. (TBIO) (Diagnostic technologies; genetic tests; equipment, reagents and other consumables with applications in molecular testing and cytogenetics)

Ears

Auris Medical Holding AG (EARS) (Switzerland: inner ear therapies)

Eyes

Imprimis Pharmaceuticals, Inc. (IMMY) (Ophthalmology and urology drug therapies)

Gastrointestinal

AzurRx BioPharma, Inc. (AZRX) (IPO October 11, 2016: Development stage biopharmaceutical company focused on gastrointestinal disorders)

Genetic Disorders

Protalix BioTherapeutics, Inc. (PLX) (Israel, biopharmaceutical company: therapeutic proteins used in the treatment of genetic disorders including Gaucher disease and Fabry disease)

Hearing Loss

GenVec, Inc. (GNVC) (Biopharmaceutical company: therapeutics and vaccines; treatments for hearing loss and balance disorders)

Heart

ARCA Biopharma, Inc. (ABIO) (Biopharmaceutical company: therapies for cardiovascular diseases)

Bellerophon Therapeutics, Inc. (BLPH) (Cardiopulmonary and cardiac diseases)

Hemostasis

Catalyst Biosciences, Inc. (CBIO) (Biopharmaceutical company: hemostasis)

Immunotherapy

Caladrius Biosciences, Inc. (CLBS) (Immunotherapy company: cell process optimization, development, and manufacturing)

Stellar Biotechnologies, Inc. (SBOT) (Immunotherapy)

Infectious Diseases

Vical Incorporated (VICL) (Biopharmaceutical company: infectious diseases through DNA delivery technologies and therapeutic approaches)

Liver

Galmed Pharmaceuticals Ltd. (GLMD) (Israel, biopharmaceutical company: oral therapy for treating liver diseases and cholesterol gallstones)

Phaserx, Inc. (PZRX) (IPO May, 18 2016: biopharmaceutical company focused on treatments for enzyme deficiencies in the liver)

Metabolic

Acasti Pharma, Inc. (ACST) (Canada, biopharmaceutical company: active pharmaceutical ingredients (API) for the management of cardiometabolic disorders)

Cymabay Therapeutics Inc. (CBAY) (Biopharmaceutical company: metabolic diseases)

Viking Therapeutics (VKTX) (IPO in April 2015: Therapeutics for patients suffering from metabolic and endocrine disorders)

MS

Opexa Therapeutics, Inc. (OPXA) (Personalized immunotherapy: multiple sclerosis, autoimmune diseases)

Muscle Health

MYOS Corporation (MYOS) (BioTherapeutics and BioNutrition company: muscle health and function)

Neurological

Brainstorm Cell Therapeutics Inc. (BCLI) (Stem cell therapies for neurodegenerative diseases)

Cerecor Inc. (CERCU) (IPO in October 2015: Biopharmaceutical company: neurological and psychiatric diseases)

Marinus Pharmaceuticals, Inc. (MRNS) (Biopharmaceutical company: neuropsychiatric therapeutics)

Prana Biotechnology Ltd. (PRAN) (Australia: neurodegenerative diseases, Alzheimer’s and Huntington diseases)

Oral Health

Oragenics, Inc. (OGEN) (Biopharmaceutical company: oral probiotics products and antibiotics for humans and companion pets)

Organ Implants

Biostage, Inc. (BSTG) (Bioengineered organ implants)

Pain

Kitov Pharamceuticals Holdings Ltd. (KTOV) (Israel: anti-inflammatory drugs that treat pain without raising blood pressure)

Pain Therapeutics (PTIE) (Biopharmaceutical company; painkillers)

Rare Diseases

Bio Blast Pharma Ltd. (ORPN) (Therapies for patients with rare and ultra-rare genetic diseases)

Regenerative Medicine  

Cesca Therapeutics Inc. (KOOL) (Cell-based therapeutics for use in regenerative medicine)

Reproductive

Repros Therapeutics Inc. (RPRX) (Biopharmaceutical company: reproductive system disorders)

Respiratory

Pulmatrix Inc. (PULM) (Biopharmaceutical company: therapies to address pulmonary disease)

Windtree Therapeutics, Inc. (WINT) (Biotechnology company: respiratory distress syndrome in premature infants)

Skin

Fibrocell Science Inc. (FCSC) (Cell and gene therapy company: rare and serious skin and connective tissue diseases)

RXI Pharmaceuticals Corporation (RXII) (Therapeutics in the areas of dermatology and ophthalmology)

Stem Cells

Cellect Biotechnology Ltd. (APOP) (IPO July 29, 2016: biotech company with functional stem cells selection platform)

Urology

Apricus Biosciences, Inc. (APRI) (Biopharmaceutical company: sexual health therapies, urology and rheumatology)

Vaccines

BiondVax Pharmaceuticals Ltd. (BVXV) (IPO in May 2015: Israel, biopharmaceutical company: flu vaccine)

Weight Management

Orexigen Therapeutics, Inc. (OREX) (Biopharmaceutical company: obesity)

Wound Care

Macrocure Ltd (MCUR) (Biopharmaceutical company: chronic and hard-to-heal wounds)