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Small-Cap Pharmaceutical Stocks

U.S. Exchanges

List of Publicly Traded Small-Cap Pharmaceutical Companies Listed on U.S. Exchanges

This list includes small-sized pharmaceutical companies with market capitalizations between 300 million and two billion dollars. We update this page at the start of every month so it is possible that during the course of a month a company’s market cap might fall below 300 million or go above two billion dollars. Additional pharmaceutical companies can be found in the following sections:

List of Pharmaceutical Companies

Large-Cap Pharmaceuticals

Mid-Cap Pharmaceuticals

Micro-Cap Pharmaceuticals

Biopharmaceutical companies are generally not included on this list of companies and can be found in our Biotech section. In parentheses you will find a short description or examples of areas of focus listed for the company.

A comparison widget that shows trend, earnings per share (EPS), P/E ratio and beta for each of the companies on this list can be accessed through the link below.

Small-Cap Pharmaceutical Industry Comparison Widget

Select the company’s link to access charts, news links and company website and social media information.

Pharmaceuticals: Small-Cap Stocks

Corcept Therapeutics Incorporated (CORT) (Disorders associated with the steroid hormone cortisol)

Impax Laboratories, Inc. (IPXL) (Generics; branded business focusing on Central Nervous System products)

Lannett Co Inc. (LCI) (Generic pharmaceuticals)

Repligen Corporation (RGEN) (Consumable products used in the process of manufacturing biological drugs)

Animal Health

Phibro Animal Health Corporation (PAHC) (Animal health and mineral nutrition company focused on animals for food production)


Eagle Pharmaceuticals, Inc. (EGRX) (Injectable products: critical care and oncology)

Heron Therapeutics, Inc. (HRTX) (Pharmaceutical products for patients suffering from cancer or pain)

Karyopharm Therapeutics Inc. (KPTI) (Drugs for the treatment of cancer and other major diseases)

Odonate Therapeutics, Inc. (ODT) (IPO December 7, 2017; pharmaceutical company: cancer)

Central Nervous System

Adamas Pharmaceuticals, Inc. (ADMS) (Chronic disorders of the central nervous system)

Supernus Pharmaceuticals, Inc. (SUPN) (Central nervous system diseases, epilepsy)


Sol-Gel Technologies Ltd. (SLGL) (IPO February 1, 2018; Israel: pharmaceutical company: dermatology)

Drug Delivery

Antares Pharma, Inc. (ATRS) (Self-injection pharmaceutical products; topical gel-based products)

Avadel Pharmaceuticals plc (AVDL) (Drug delivery, anesthesia related products)

Insys Therapeutics, Inc. (INSY) (Supportive care products: spray drug delivery technology)

Ear, Nose and Throat

OptiNose, Inc. (OPTN) (IPO October 13, 2017; specialty pharmaceutical company: ear, nose and throat products)


Aerie Pharmaceuticals, Inc. (AERI) (Therapies for the treatment of patients with glaucoma)


Amphastar Pharmaceuticals, Inc. (AMPH) (Generic and branded injectable and inhalation products)

Teligent, Inc. (TLGT) (Generics: topical and injectable prescription medicines)


Esperion Therapeutics, Inc. (ESPR) (LDL-C lowering therapies)

Infectious Diseases

Achillion Pharmaceuticals, Inc. (ACHN) (Complement-related diseases and infectious diseases)


Aquinox Pharmaceuticals, Inc. (AQXP) (Canada: Drug candidates to treat inflammation and cancer)


AMAG Pharmaceuticals, Inc. (AMAG) (Chronic kidney disease, oral rinse for oral mucositis, umbilical cord blood stem cell collection and storage)

Pain Management

Collegium Pharmaceutical, Inc. (COLL) (IPO in May 2015: Products designed to treat chronic pain while deterring drug abuse/misuse)

Depomed, Inc. (DEPO) (Pain and other central nervous system conditions)

Flexion Therapeutics, Inc. (FLXN) (Pain therapies for the sufferers of musculoskeletal diseases)

Pacira Pharmaceuticals, Inc. (PCRX) (Pharmaceutical products for use in hospitals and ambulatory surgery centers)

Products and Services

Cambrex Corporation (CBM) (Products and services designed to accelerate and improve the development and commercialization of new and generic therapeutics)


Aclaris Therapeutics, Inc. (ACRS) (IPO in October 2015: Specialty pharmaceutical company: dermatologic treatments)

Foamix Pharmaceuticals Ltd. (FOMX) (Israel: treatment of moderate-to-severe acne and impetigo)

Novan, Inc. (NOVN) (IPO September 21, 2016: late stage pharmaceutical company; dermatology therapies)


Dova Pharmaceuticals, Inc. (DOVA) (IPO June 29, 2017; pharmaceutical company: thrombocytopenia)

Women’s Health

TherapeuticsMD, Inc. (TXMD) (Products specifically for women: prescription, generic prescription, and over-the-counter products)

Related Links:

Publicly Traded Companies by Sector and Industry

List of Pharmaceutical ETFs

List of Healthcare Companies